New Aspects In Medicinal Plants And Pharmacognosy (2025)

International Journal of Applied And Pure Science and Agriculture PHYTOCHEMICAL ANALYSIS AND ANTICANCEROUS ACTIVITY OF SELECTED MEDICINAL PLANTS

Detection of phytoconstituents in plants makes the primary step in drug evaluation. In the present study, preliminary phytochemical studies were conducted on the Andrographis paniculata, Nees., Centella asiatica, L. and Murraya koenigii, L.. Extracts were prepared in ethanol, methanol and distilled water using powdered leaves. For the detection of primary and secondary metabolites preliminary qualitative phytochemical tests were conducted based on standard procedures described by Harbourn. Among the three constituents selected for study, carbohydrate was the major primary metabolite. Alkaloids, tannins and phenols were also present in all. As the present study is qualitative analysis, it helped in detection of various phytoconstituents in the selected plants under study. Anticancerous activity of Andrographis paniculata, Nees., Centella asiatica, L. and Murraya koenigii,L. were studied.

An Evaluation of the Phytochemical Properties and Anticancer Activity of Selected Native Medicinal Plants

Journal of Advanced Scientific Research

In the present study, phytochemical constituents of medicinal plants were evaluated from their ethanolic extracts, such as Andrographis paniculata, Centella asiatica, Psidium guajava and Solanum trilobatum. The extracts were subjected to a qualitative phytochemical screening using a standard procedure. Our study has identified phytocompounds present in leaf extracts of Andrographis paniculata, Centella asiatica, Psidium guajava and Solanum trilobatum using IR and GC-MS spectroscopy. An anticancer activity was performed on each of these extracts using two human cancer cell lines, a colon cancer cell line (HCT116) and a cervical cancer cell line (HeLa). Despite the four medicinal plants extracts having comparable anticancer activity, the ethanolic extracts of Andrographis paniculata and Solanum trilobatum show higher anticancer activity than Centella asiatica and Psidium guajava. The Andrographis paniculata (IC50=27.54 μg/ml HeLa and 30.19 μg/ml HCT116) and Solanum trilobatum (IC50=32...

PHYTOCHEMICAL ANALYSIS AND ANTICANCEROUS ACTIVITY OF SELECTED MEDICINAL PLANTS

Detection of phytoconstituents in plants makes the primary step in drug evaluation. In the present study, preliminary phytochemical studies were conducted on the Andrographis paniculata, Nees., Centella asiatica, L. and Murraya koenigii, L.. Extracts were prepared in ethanol, methanol and distilled water using powdered leaves. For the detection of primary and secondary metabolites preliminary qualitative phytochemical tests were conducted based on standard procedures described by Harbourn. Among the three constituents selected for study, carbohydrate was the major primary metabolite. Alkaloids, tannins and phenols were also present in all. As the present study is qualitative analysis, it helped in detection of various phytoconstituents in the selected plants under study. Anticancerous activity of Andrographis paniculata, Nees., Centella asiatica, L. and Murraya koenigii,L. were studied.

Anticancer activity of Medicinal plant extract-A re view

2010

Traditional medicine has a long history of serving peoples all over the world. India is without doubt a herbal hub. Medicin al plants that are native to India and their use in various traditiona l systems of medicine are indeed awe-inspiring. The ethnobotany and ubiquitous plants provide a rich resource for Natural drug research a nd development. In recent years, the use of traditional medicine infor mation on plant research received considerable interest. The medici nal plants contain several phytochemicals such as vitamins, carotenoid s, terpenoids, flavonoids, polyphenols, alkaloids, tannins, saponi ns, enzymes, minerals etc. These phytochemicals possess antioxid ant activities, which, prevent or can be used in the treatment of m any diseases, including cancer. There are the several medicinal p lants all over the world, including India, which are being used tradit ionally for the prevention and treatment of cancer. The present pap er is a comprehensive review of different literat...

Mexican medicinal plants used for cancer treatment: Pharmacological, phytochemical and ethnobotanical studies

Lancet, 2011

Aim of the study: This review provides a summary of Mexican medicinal flora in terms of ethnobotanical, pharmacology, and chemistry of natural products related to anticancer activity. Materials and methods: Bibliographic investigation was carried out by analyzing recognized books and peer-reviewed papers, consulting worldwide accepted scientific databases from the last five decades. Mexican plants with attributed anti-cancer properties were classified into six groups: (a) plant extracts that have been evaluated for cytotoxic effects, (b) plant extracts that have documented anti-tumoral effects, (c) plants with active compounds tested on cancer cell lines, (d) plants with novel active compounds found only in Mexican species, (e) plants with active compounds that have been assayed on animal models and (f) plants with anti-cancer ethnopharmacological references but without scientific studies.

Evaluating medicinal plants for anticancer activity

TheScientificWorldJournal, 2014

Plants have been used for medical purposes since the beginning of human history and are the basis of modern medicine. Most chemotherapeutic drugs for cancer treatment are molecules identified and isolated from plants or their synthetic derivatives. Our hypothesis was that whole plant extracts selected according to ethnobotanical sources of historical use might contain multiple molecules with antitumor activities that could be very effective in killing human cancer cells. This study examined the effects of three whole plant extracts (ethanol extraction) on human tumor cells. The extracts were from Urtica membranacea (Urticaceae), Artemesia monosperma (Asteraceae), and Origanum dayi post (Labiatae). All three plant extracts exhibited dose- and time-dependent killing capabilities in various human derived tumor cell lines and primary cultures established from patients' biopsies. The killing activity was specific toward tumor cells, as the plant extracts had no effect on primary cult...

Traditionally Used Medicinal Plants with Anticancer Effect: A Review

International Journal of Pharmaceutical Sciences Review and Research, 2020

Cancer is the second major cause of death after cardiovascular diseases. It is a group of many closely related diseases. Several synthetic drugs are used to cure this disease but they have their toxicity and hence a number of research activities is going on to investigate the natural plant derived chemotherapeutic agents. More than 50% of modern drugs in clinical use are of natural agents. In recent years owing to the concern of side effects people prefer more and more use of natural plant products for cancer. For these reasons, World Health Organization (WHO) supports the use of traditional medicines which are efficacious and less toxic compared with conventional agents. The basic aim of this review is to highlight on the potential of newly discovered anticancer compounds from traditional medicinal plants to be used as leads for anticancer drug development. 85 different plant sources have been listed in the present review along with the phytoconstituents present in these plants possessing anticancer potential. The present paper is a comprehensive review of different literature sources. It will be helpful to explore the medicinal value of the herbal plants against the cancer and for the new drug discovery from them for the researchers and scientists around the world.

Phytochemical analysis and anticancer screening of some indigenous plants grown in Saudi Arabia

PHYTOCHEMICAL CONTENTS AND ANTITUMOR ACTIVITY OF SOME MEDICINAL PLANT EXTRACTS

IAEME Publications, 2020

Background: Several plants can be used to extract phytochemicals and compounds with dif erent bioactivities, including antioxidant, anti-inflammatory, and anticancer characteristics. Using plant extracts with bioactive activities is superior to the usage of synthetic chemicals present in drug production. Method: Determination chemical composition were performed for plant leave powder. Aqueous, methanolic and ethanolic extracts from Calendula tripterocarpa and Lepidium sativum were prepared and estimation the total phenolic and flavonoid content. Identified of phenolic and flavonoid compounds using HPLC. Antitumor activity of extracts on cell line (HEPG2 and MCF-7) were performed and estimated. Results: Calendula tripterocarpa leaves methanolic extract have the highest content of both total phenols and flavonoids, which were 144.03 mg GAE/g and 25.01 mg QE/g, respectively. While, the total polyphenols and flavonoids of Lepidium sativum seeds, were 107.21 mg GAE/g and 12.18 mg QE/g, respectively. The results of antitumor activity showed the dead cell percentage by methanolic extract of Calendula tripterocarpa were (510.1 and533.4) of HEPG2 and MCF-7) at concentration of 15μg/ml. Followed by methanolic extract of Lepidium sativum, which were (407.2 and 452.5) of HEPG2 and MCF-7) at the same a concentration. Increasing the concentration to 30and 60μg/ml the resulted in more higher percentage of HEPG2 and MCF-7dead cell. Conclusion: Calendula tripterocarpa and Lepidium sativum have antitumor activity against liver and breast cancers cell lines, and the most ef ective extract of both plants was the methanolic extract

Pharmacological activities of selected plant species and their phytochemical analysis

In this study, four plants [Chrozophora hierosolymitana Spreng (Euphorbiaceae), Ephedra gerardiana Wall. ex Stapf (Ephedraceae), Chrysanthemum leucanthemum L. (Astraceae), and Quercus dilatata L. (Fegaceae)] collected from different regions of Pakistan were screened to identify any chemotherapeutic agents present in them. Seven methanol extracts of these plants (leaf, stem, and root extracts of C. hierosolymitana; stem and root extracts of E. gerardiana; aerial parts of C. leucanthemum, and aerial parts of Q. dilatata) were examined for cytotoxicity using brine shrimp assay, antitumor activity using potato disc assay, and phytotoxicity activity using radish seed bioassay. Two methanol plant extracts, that is, leaf extract of C. hierosolymitana and root extract of E. gerardiana showed significant brine shrimp cytotoxicity activity ranging from 171.55 to 523.8 ppm. Six of the seven extracts exhibited tumor inhibition at all the three concentrations tested, ranging from 10 to 80%. All ...